9 Best Strains for Anxiety: Top Choices for 2025

The prevalence of anxiety disorders is a growing concern worldwide, affecting over 40 million adults in the United States alone. As society seeks alternative forms of relief, the legalization of cannabis has sparked growing interest in its potential to alleviate symptoms of anxiety. This article will outline the nine best cannabis strains for managing stress in 2024 and highlight the most important factors to consider when choosing a suitable variety for your specific needs.

Understanding Anxiety and Cannabis

Anxiety is characterized by feelings of worry, fear, and unease, with those affected commonly exhibiting symptoms such as increased heart rate, rapid breathing, and restlessness. Both anecdotal evidence and peer-reviewed studies have explored the potential benefits of cannabis in reducing anxiety. This is because cannabis contains compounds that interact with the body’s endocannabinoid system, which is directly involved in regulating stress and anxiety.

A study on the use of CBD for the treatment of anxiety published by the NCBI has concluded that existing pre-clinical and clinical evidence supports a potential role for cannabis as a novel treatment for anxiety disorders. The research reviewed in this study illustrates its capability to generate anxiety-reducing effects in preclinical models and the potential of high-CBD products to induce acute anxiolytic effects, which can support stress relief and promote relaxation.

The Role of THC and CBD in Anxiety Relief

THC and CBD are the two most well-known compounds found in cannabis. The main difference between them is that THC has psychoactive effects, meaning it can make you feel “high,” while CBD is non-psychoactive. Studies have found that cannabis with lower levels of THC can decrease feelings of anxiety, but higher doses can often increase them. On the other hand, the use of any dosage of CBD has been found to reduce stress by directly interacting with serotonin receptors.

By achieving the right balance between the two compounds, it is possible to harness the potential therapeutic benefits. This synergy is often referred to as the entourage effect. It helps to minimize the potential for increased anxiety or paranoia that is frequently associated with high-THC strains and products. This can lead to more effective treatment for individuals who want to benefit from the therapeutic properties of cannabis while minimizing the psychoactive high.

Best Indica Strains for Anxiety

OG Kush cannabis flower.

If you’re looking for the best marijuana for anxiety, consider Indica strains with moderate THC levels and high CBD levels. These strains are known for their iconic body stone and calming properties that can reduce stress and tension. They’re not as sweet as many sativa varieties and have higher levels of terpenes, such as myrcene, which is believed to have anti-inflammatory properties and soothing effects, significant for those managing an anxiety disorder.

1. OG Kush

OG Kush is frequently listed as one of the best weed strains for anxiety management due to its unique characteristics. With a high but not overwhelming THC content, it is known to induce feelings of euphoria and relaxation. Its terpene profile, featuring myrcene, limonene, and caryophyllene, is associated with a calming effect. The strain’s relaxing, body high effectively alleviates physical tension, while its ability to create euphoria can help shift the focus away from anxious thoughts.

2. Granddaddy Purple

Granddaddy Purple, or GDP, is an iconic Indica-dominant strain appreciated for its deeply relaxing effects and distinctive deep purple color. This strain is a cross between Purple Urkle and Big Bud, resulting in a complex flavor profile with hints of grape and berry. With a high myrcene content, this strain is excellent for reducing anxiety, promoting relaxation, and relieving chronic pain. Its soothing properties make this purple weed strain especially beneficial for improving sleep quality and reducing stress levels.

3. Mango Sherbet

Mango Sherbet features light green buds that are densely covered in trichomes. Its aroma is delightful, offering sweet tropical notes of mango, the creamy sweetness of sherbet, hints of whipped cream, and a subtle touch of strawberry. Upon consumption, it induces an uplifting euphoria that soothes the mind before transitioning into a relaxing body high, making it a promising option for relieving any unwanted stress or tension.

Best Sativa Strains for Anxiety

Sativa-dominant strains are known for their diverse and complex terpene profiles, often featuring a delightful combination of sweet, citrusy, and fruity notes. These strains have gained recognition for their ability to provide relief without inducing sedation or lethargy. Renowned for their energizing and uplifting effects, they are increasingly popular for reducing unwanted stress and tension while promoting alertness and a more optimistic mindset.

1. Sour Diesel

Sour Diesel, also known as Sour D, is a widely recognized cannabis strain recognized for its distinctive gassy aroma and stimulating effects. It is considered beneficial for its potential to alleviate anxiety through its mood-enhancing and stress-reducing qualities. It’s also known to elevate energy levels, promote motivation, and offer a clear-headed high, allowing users to remain focused and alert. Certain variations also encompass a well-balanced THC-to-CBD ratio.

2. Guzzurple

Guzzurple is a highly sought-after strain acknowledged for its vibrant purple color and energizing, psychedelic effects. Its terpene profile boasts a delightful blend of fruity and sweet flavors, complemented by subtle notes of berries and grapes. This strain’s calming and mood-boosting properties make it an excellent choice for managing stress. At the same time, the enjoyable combination of fruity and sweet flavors offers a delightful sensory experience for all.

3. Hella Jelly

Hella Jelly is well-regarded in the cannabis community for its ability to provide effective stress relief without overwhelming the user. Its abundant CBD content enhances its therapeutic effects, while its terpene profile evokes a delightful aroma reminiscent of fresh strawberries and grapes. Noteworthy levels of linalool and limonene contribute to its distinctive scent and are recognized for their calming properties. It’s perfect for keeping you uplifted during the day.

Best Hybrid Strains for Anxiety

Blueberry Pancakes cannabis flower.

Hybrid strains combine the desirable traits of both indica and sativa, resulting in a complex array of beneficial cannabinoids that are particularly well-suited for individuals managing anxiety. These strains deliver the calming properties traditionally associated with indica varieties without inducing sedation or exacerbating feelings of anxiety while also providing the uplifting and stimulating effects typically attributed to classic sativa strains.

1. Blueberry Pancakes

Blueberry Pancakes is a delightful sativa-dominant hybrid celebrated for its sweet, dessert-like terpene profile. The strain’s dense, bright green buds adorned with glistening trichomes add to its visual appeal. The comforting, uplifting high promotes mental clarity and fosters a sense of well-being and positivity. Renowned for managing stress without inducing sedation, Blueberry Pancakes has become a popular choice for many users seeking a joyful experience.

2. COB Salad

The COB Salad strain was created by crossing Mountaintop Mint #1, OG Kush, and Haze. Although the Haze strain is part of its lineage, don’t worry; COB Salad features moderate levels of both THC and CBD, offering a balance of beneficial cannabinoids. When consumed, it begins with heightened cerebral creativity and talkativeness, effectively easing worries before a subtle body stone takes hold. This leaves you relaxed but alert, making it a perfect strain for daytime use.

3. Guzzlerz

With an impressive parental lineage of Skittlez and Triangle Kush, Guzzlers is a balanced hybrid noted for its high cannabinoid content and energetic gassy terpene profile. Its effects unfold gently, with subtle uplifting euphoria that gradually enhances mental relaxation while soothing the body. This makes Guzzlers an excellent option for individuals seeking anxiety relief without feeling excessively sedated or impaired.

How to Choose the Right Strain for Your Anxiety

The effects of cannabis can vary widely from person to person due to several contributing factors, including individual tolerance levels, metabolic rate, body weight, and the dosage of the marijuana consumed. While some individuals may find that THC helps alleviate their anxiety, others may experience an increase in feelings of anxiousness, paranoia, or discomfort. So, consider these factors and check out the strain descriptions to make an informed choice when shopping for cannabis strains for anxiety.

For those considering using cannabis for anxiety, it’s essential to seek guidance from a certified healthcare professional. They can provide valuable information on potential side effects and interactions with any existing medications or conditions. Additionally, consulting with a knowledgeable member of staff at your local dispensary can help determine the best marijuana strain, consumption method, and dosage to suit your specific needs.

Potential Side Effects and Considerations

For first-time users, it’s important to start with a low dose. For example, if you’re smoking a joint, consider taking only one or two puffs and then wait for the effects to become noticeable. Giving your body enough time to respond before consuming more is essential. 

If you start feeling overwhelmed or uncomfortable, it’s recommended that you slow down and wait before taking more. Additionally, you can check out our article on “How to Get Unhigh” for more information.

As previously mentioned, high-THC strains have been associated with an increase in anxiety, and using cannabis to manage anxiety could potentially lead to a variety of side effects. This is especially true for Europeans who sometimes mix it with tobacco, as these side effects may include short-term memory loss, impaired motor coordination, increased heart rate, and redness in the eyes, as well as dry mouth. Therefore, always consult with a healthcare professional beforehand.

Best Cannabis Strains For Anxiety – Final Thoughts

In conclusion, gaining a better understanding of the potential benefits of cannabis can help individuals make informed decisions about using cannabis for anxiety relief. However, it is crucial to consult healthcare professionals before doing so. With advancing research, there is growing optimism for the development of a broader range of treatments, offering hope to the many individuals dealing with anxiety and other mental health disorders.